CXADR CLIA Kit for Human(Homo sapiens) | EIAab.comCXADR CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CXADR(Gene name) > Human

CXADR (Gene name),

Coxsackievirus and adenovirus receptor (Protein name ), CXAR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CXADR(CAR);

Protein name:

Coxsackievirus and adenovirus receptor(CAR;hCAR);

Alternative:

Coxsackievirus B-adenovirus receptor;CVB3-binding protein;HCVADR;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Probably homodimer formed by 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Interacts with DNAJC7. Probably part of a complex containing CXADR, HSP90AA1 and DNAJC7 (By similarity). Interacts with adenovirus subgroup A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins and acts as a receptor for these viruses.

Function:

Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.

Subcellular Location:

Isoform 5 Secreted

Protein Attributes:

Sequence length:

365

Sequence:

50:

100:

150:

200:

250:

300:

350:

365:

IPVMIPAQSK | DGSIV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P78310

KEGG:

hsa:1525

Pfam:

PF07686

Pfam:

PF07679

String:

P78310

UniGene:

Hs.627078

UniGene:

Hs.634837

MIM:

602621

STRING:

9606.ENSP00000284878

Uniprot:

P78310

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ELISA Kit for Human CAR

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E13929r

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96T

ELISA Kit for Human CAR

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E13929m

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ELISA Kit for Human CAR

Cat.:

E13929h

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ELISA Kit for Human CAR

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CLIA Kit for Human CAR

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CLIA Kit for Human CAR

Cat.:

U13929h

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MSDS:

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Packing:

96T

CLIA Kit for Human CAR

Cat.:

U13929m

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MSDS:

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Packing:

96T

CLIA Kit for Human CAR

MSDS:

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Polyclonal Antibody for Human CAR

Monoclonal Antibody for Human CAR

Protein for Human CAR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses."
Tomko R.P. , Xu R. , Philipson L.
Proc. Natl. Acad. Sci. U.S.A.94:3352-3356(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS A VIRUS RECEPTOR;TISSUE SPECIFICITY
2.

"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5."
Bergelson J.M. , Cunningham J.A. , Droguett G. , Kurt-Jones E. , Krithivas A. , Hong J.S. , Horwitz M.S. , Crowell R.L. , Finberg R.W.
Science275:1320-1323(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene."
Bowles K.R. , Gibson J. , Wu J. , Shaffer L.G. , Towbin J.A. , Bowles N.E.
Hum. Genet.105:354-359(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor."
He Y. , Chipman P.R. , Howitt J. , Bator C.M. , Whitt M.A. , Baker T.S. , Kuhn R.J. , Anderson C.W. , Freimuth P. , Rossmann M.G.
Nat. Struct. Biol.8:874-878(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection."
Doerner A. , Xiong D. , Couch K. , Yajima T. , Knowlton K.U.
J. Biol. Chem.279:18497-18503(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5);INTERACTION WITH COXSACKIEVIRUS TYPE B3;SUBCELLULAR LOCATION
6.

"Putative regulatory domains in the human and mouse CAR genes."
Andersson B. , Tomko R.P. , Andersson K. , Darban H. , Oncu D. , Mizra M. , Sollerbrant K. , Sonnhammer E. , Philipson L.
Submitted (2000-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Identification and characterisation of CAR 4/6 as a new splice variant of the Coxsackie adenovirus receptor (CAR)."
Dietel M.
Submitted (2010-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7)
8.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Cervix.
9.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
10.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
11.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Cervix.
14.

"Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers."
Fechner H. , Haack A. , Wang H. , Wang X. , Eizema K. , Pauschinger M. , Schoemaker R.G. , van Veghel R. , Houtsmuller A.B. , Schultheiss H.-P. , Lamers J.M.J. , Poller W.
Gene Ther.6:1520-1535(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
tissue: Liver.
15.

"The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F."
Roelvink P.W. , Lizonova A. , Lee J.G.M. , Li Y. , Bergelson J.M. , Finberg R.W. , Brough D.E. , Kovesdi I. , Wickham T.J.
J. Virol.72:7909-7915(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS SUBGROUPS A/C/D/E/F FIBER PROTEINS
16.

"Expression of the adenovirus receptor and its interaction with the fiber knob."
Tomko R.P. , Johansson C.B. , Totrov M. , Abagyan R. , Frisen J. , Philipson L.
Exp. Cell Res.255:47-55(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS FIBER PROTEIN;MUTAGENESIS OF 70-VAL--ILE-72
17.

"The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus."
Martino T.A. , Petric M. , Weingartl H. , Bergelson J.M. , Opavsky M.A. , Richardson C.D. , Modlin J.F. , Finberg R.W. , Kain K.C. , Willis N. , Gauntt C.J. , Liu P.P.
Virology271:99-108(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COXSACKIEVIRUS GROUP B CAPSID PROTEINS
18.

"Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene."
Thoelen I. , Magnusson C. , Tagerud S. , Polacek C. , Lindberg M. , Van Ranst M.
Biochem. Biophys. Res. Commun.287:216-222(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
19.

"Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections."
Noutsias M. , Fechner H. , de Jonge H. , Wang X. , Dekkers D. , Houtsmuller A.B. , Pauschinger M. , Bergelson J.M. , Warraich R. , Yacoub M. , Hetzer R. , Lamers J.M.J. , Schultheiss H.-P. , Poller W.
Circulation104:275-280(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
20.

"Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting."
Cohen C.J. , Gaetz J. , Ohman T. , Bergelson J.M.
J. Biol. Chem.276:25392-25398(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-318 AND 345-LEU--MET-348
21.

"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction."
Cohen C.J. , Shieh J.T.C. , Pickles R.J. , Okegawa T. , Hsieh J.-T. , Bergelson J.M.
Proc. Natl. Acad. Sci. U.S.A.98:15191-15196(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH TJP1;FUNCTION
22.

"Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape."
Walters R.W. , Freimuth P. , Moninger T.O. , Ganske I. , Zabner J. , Welsh M.J.
Cell110:789-799(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH CTNNB1;INTERACTION WITH HUMAN ADENOVIRUS FIBER PROTEIN;FUNCTION
23.

"Fatty acid modification of the coxsackievirus and adenovirus receptor."
van't Hof W. , Crystal R.G.
J. Virol.76:6382-6386(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-259 AND CYS-260;SUBCELLULAR LOCATION;MUTAGENESIS OF 259-CYS-CYS-260
24.

"The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)."
Sollerbrant K. , Raschperger E. , Mirza M. , Engstroem U. , Philipson L. , Ljungdahl P.O. , Pettersson R.F.
J. Biol. Chem.278:7439-7444(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LNX
25.

"Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs."
Shaw C.A. , Holland P.C. , Sinnreich M. , Allen C. , Sollerbrant K. , Karpati G. , Nalbantoglu J.
BMC Cell Biol.5:42-42(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY (ISOFORMS 1 AND 2)
26.

"The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction."
Coyne C.B. , Voelker T. , Pichla S.L. , Bergelson J.M.
J. Biol. Chem.279:48079-48084(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ;SUBCELLULAR LOCATION
27.

"A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth."
Ashbourne-Excoffon K.J.D. , Hruska-Hageman A.M. , Klotz M. , Traver G.L. , Zabner J.
J. Cell Sci.117:4401-4409(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAIAP1; DLG4 AND PRKCABP
28.

"Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils."
Zen K. , Liu Y. , McCall I.C. , Wu T. , Lee W. , Babbin B.A. , Nusrat A. , Parkos C.A.
Mol. Biol. Cell16:2694-2703(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AMICA1;DOMAIN;FUNCTION
29.

"JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
Luissint A.C. , Lutz P.G. , Calderwood D.A. , Couraud P.O. , Bourdoulous S.
J. Cell Biol.183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LEUKOCYTE MIGRATION;INTERACTION WITH AMICA1
30.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306 AND SER-332;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
31.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
32.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
33.

"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR."
Bewley M.C. , Springer K. , Zhang Y.-B. , Freimuth P. , Flanagan J.M.
Science286:1579-1583(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 21-144 IN COMPLEX WITH HUMAN ADENOVIRUS 12 FIBER PROTEIN
34.

"Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution."
van Raaij M.J. , Chouin E. , van der Zandt H. , Bergelson J.M. , Cusack S.
Structure8:1147-1155(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 15-140;DOMAIN
35.

"Solution structure of the coxsackievirus and adenovirus receptor domain 1."
Jiang S. , Jacobs A. , Laue T.M. , Caffrey M.
Biochemistry43:1847-1853(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 21-144

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